Conus Medullaris Metastasis in a Patient with Triple-positive Breast Cancer
Keywords:
Breast cancer, conus medullaris, metastasisAbstract
Although brain metastasis is usual in breast cancer, metastasis of the conus medullaris is extremely infrequent. Herein, we present the first case of triple-positive subtype breast cancer with conus medullaris metastasis. The patient admitted with paraplegia and neurological dysfunction improved after the removal of the mass, followed by radiotherapy. We also discuss the clinical characteristics and available therapies for conus medullaris metastases.
References
1. Allemani C, Matsuda T, Di Carlo V, Harewood R, Matz M, et al. Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet. 2018;391:1023-75.
2. Vellayappan BA, Chao ST, Foote M, Guckenberger M, Redmond KJ, et al. The evolution and rise of stereotactic body radiotherapy (SBRT) for spinal metastases. Expert Rev Anticancer Ther. 2018;18:887-900.
3. Hrabalek L. Intramedullary spinal cord metastases: review of the literature. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2010;154:117-22.
4. Mavani SB, Nadkarni TD, Goel NA. Intramedullary conus metastasis from carcinoma lung. J Craniovertebr Junction Spine. 2013;4:40-2.
5. Arciero CA, Guo Y, Jiang R, Behera M, O’Regan R, et al. ER(+)/HER2(+) breast cancer has different metastatic patterns and better survival than ER(-)/HER2(+) breast cancer. Clin Breast Cancer. 2019;19:236-45.
6. Zebrowski A, Wilson L, Lim A, Stebbing J, Krell J. Intramedullary spinal cord metastases in breast cancer are associated with improved longer-term systemic control. Future Oncol. 2010;9:1517-9.
7. Kalayci M, Cağavi F, Gül S, Yenidünya S, Açikgöz B. Intramedullary spinal cord metastases: diagnosis and treatment - an illustrated review. Acta Neurochir (Wien). 2004;146:1347-54.
8. Payer S, Mende KC, Westphal M, Eicker SO. Intramedullary spinal cord metastases: an increasingly common diagnosis. Neurosurg Focus. 2015;39:15.
9. Choi HC, Yoon DH, Kim SC, Cho KH, Kim SH. Two separate episodes of intramedullary spinal cord metastasis in a single patient with breast cancer. J Korean Neurosurg Soc. 2010;48:162-5.
10. Ebner FH, Roser F, Acioly MA, Schoeber W, Tatagiba M. Intramedullary lesions of the conus medullaris: differential diagnosis and surgical management. Neurosurg Rev. 2009;32:287-300.
11. Burton MR, De Jesus O, Mesfin FB. Conus and cauda equina tumors, in StatPearls. 2022, StatPearls Publishing Copyright© 2022, StatPearls Publishing LLC: Treasure Island (FL).
12. Dam-Hieu P, Seizeur R, Mineo JF, Metges JP, Meriot P, et al. Retrospective study of 19 patients with intramedullary spinal cord metastasis. Clin Neurol Neurosurg. 2009;111:10-7.
13. Gazzeri R, Telera S, Galarza M, Callovini GM, Isabella S, et al. Surgical treatment of intramedullary spinal cord metastases: functional outcome and complications-a multicenter study. Neurosurg Rev. 2021;44:3267-75.
14. Hurvitz SA, O’Shaughnessy J, Mason G, Yardley DA, Jahanzeb M, et al. Central nervous system metastasis in patients with HER2-positive metastatic breast cancer: patient characteristics, treatment, and survival from SystHERs. Clin Cancer Res. 2019;25:2433-41.
15. Hsu KC, Li TY, Chu HY, Chen LC, Chang ST, et al. Conus medullaris metastasis in breast cancer: report of a case and a review of the literature. Surg Today. 2013;43:910-4.
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