Early-onset Neonatal Septicemia Caused by Staphylococcus lentus: A Rare Case Report with Literature Review

Authors

Keywords:

Newborn, septicemia, Staphylococcus lentus

Abstract

Coagulase-negative Staphylococci, previously considered harmless, are now recognized as significant pathogens in neonatal sepsis. Staphylococcus lentus, part of the Staphylococcus sciuri group, is predominantly found in animals but can colonize humans and cause severe infections. These microorganisms are known for their high antibiotic resistance, with methicillin resistance rates exceeding 70%. Vancomycin is the preferred treatment for neonatal sepsis caused by these pathogens. This case report aims to present a rare case of early-onset neonatal sepsis caused by Staphylococcus lentus, a pathogen not commonly associated with humans.

References

1. Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, et al. The global burden of paediatric and neonatal sepsis: a systematic review. Lancet Respir Med. 2018;6:223-30.

2. Dhudasia MB, Flannery DD, Pfeifer MR, Puopolo KM. Updated guidance: prevention and management of perinatal group B streptococcus infection. Neoreviews. 2021;22:e177-88.

3. Simonsen KA, Anderson-Berry AL, Delair SF, Davies HD. Early-onset neonatal sepsis. Clin Microbiol Rev. 2014;27:21-47.

4. Mularoni A, Madrid M, Azpeitia A, Valls i Soler A. The role of coagulasenegative staphylococci in early onset sepsis in a large European cohort of very low birth weight infants. Pediatr Infect Dis J. 2014;33:e121-5.

5. Hira V, Kornelisse RF, Sluijter M, Kamerbeek A, Goessens WH, et al. Colonization dynamics of antibiotic-resistant coagulase-negative

Staphylococci in neonates. J Clin Microbiol. 2013;51:595-7.

6. Venkatesh MP, Placencia F, Weisman LE. Coagulase-negative staphylococcal infections in the neonate and child: an update. Semin Pediatr Infect Dis. 2006;17:120-7.

7. Klingenberg C, Aarag E, Rønnestad A, Sollid JE, Abrahamsen TG, et al. Coagulase-negative staphylococcal sepsis in neonates. Association between antibiotic resistance, biofilm formation and the host inflammatory response. Pediatr Infect Dis J. 2005;24:817-22.

8. Stepanovic S, Dakic I, Morrison D, Hauschild T, Jezek P, et al. Identification and characterization of clinical isolates of members of the Staphylococcus sciuri group. J Clin Microbiol. 2005;43:956-8.

9. Stepanovic S, Jezek P, Vukovic D, Dakic I, Petrás P. Isolation of members of the Staphylococcus sciuri group from urine and their relationship to urinary tract infections. J Clin Microbiol. 2003;41:5262-4.

10. Padari H, Oselin K, Tasa T, Metsvaht T, Lõivukene K, Lutsar I. Coagulase negative staphylococcal sepsis in neonates: do we need to adapt vancomycin dose or target? BMC Pediatr. 2016;16:206.

11. Rivera M, Dominguez MD, Mendiola NR, Roso GR, Quereda C. Staphylococcus lentus peritonitis: a case report. Perit Dial Int. 2014;34:469-70.

12. Mazal C, Sieger B. Staphylococcus lentus: The troublemaker. Int J Infect Dis. 2010;14:e397.

13. Karachalios GN, Michelis FV, Kanakis KV, Karachaliou I, Koutri R, et al. Splenic abscess due to Staphylococcus lentus: a rare entity. Scand J Infect Dis. 2006;38:708-10.

14. Hay CY, Sherris DA. Staphylococcus lentus Sinusitis: a new sinonasal pathogen. Ear Nose Throat J. 2020;99:NP62-3.

Published

30.11.2023

How to Cite

Rustamqizi, N., Mukhtarova, S., & Elbayiyev, S. (2023). Early-onset Neonatal Septicemia Caused by Staphylococcus lentus: A Rare Case Report with Literature Review. Caucasian Medical Journal, 1(3), 42–44. Retrieved from https://caucasianmedj.com/index.php/pub/article/view/23

Issue

Section

Case Report