Good Syndrome Associated Enteropathy: A Case Report

Abstract

Good syndrome (GS) is a rare, late-onset primary immunodeficiency disorder characterized by the presence of thymoma and hypogammaglobulinemia, with no familial inheritance. Immunological abnormalities in GS include defects in both humoral and cellular immunity. We present the case of a patient with GS who developed chronic diarrhea. Unlike other reported cases of GS-associated enteropathy in the literature, this case exhibited similarities to common variable immunodeficiency-related enteropathy. The patient’s chronic diarrhea was unresponsive to intravenous immunoglobulin therapy but showed significant improvement with steroids and infliximab. This case highlights the potential for atypical presentations of GS-associated enteropathy and underscores the importance of considering alternative therapeutic strategies, including immunomodulatory agents, in refractory cases.