Role of Hypoxia-Inducible Factors (HIFs) in Liver Diseases
DOI:
https://doi.org/10.67076/cmj.2026.v4n1.04Keywords:
Hypoxia-inducible factor, liver cirrhosis, hypoxia, HIF-1α, HIF-2αAbstract
Hypoxia-inducible factors (HIFs) are key transcription factors that regulate cellular adaptation to low oxygen conditions. In recent years, their role in the pathogenesis of liver diseases has gained increasing attention. In this study, the role of HIFs in fibrogenesis and disease progression was evaluated based on a clinical case with impaired liver function. The findings suggest that elevated HIF levels are associated with activation of hypoxia-related pathways and enhanced fibrogenic processes in the liver. This case suggests that elevated serum HIF levels may reflect active fibrogenesis and disease progression in liver cirrhosis.
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